Joe Rogan Experience #2537 - David Sinclair · Aired Aug 7, 2026
Claim summary · not a verbatim quotation
A 2012 study showed that NMN allows animals to grow new blood vessels by eliminating a protein that accumulates with age.
The finding
What the evidence shows
The Sinclair lab study on NMN restoring blood vessel growth in older mice was published in Cell in 2018, not 2012, and the mechanism involved restoring an NAD+ dependent signaling pathway rather than simply eliminating one protein. Treated mice regained capillary density and saw a 56 to 80 percent boost in endurance.
Read the supporting source · news.mit.edu ↗Quick answer & review status
Quick answer
Is it true that a 2012 study showed that NMN allows animals to grow new blood vessels by eliminating a protein that accumulates with age?
No, not as stated. The Sinclair lab study on NMN restoring blood vessel growth in older mice was published in Cell in 2018, not 2012, and the mechanism involved restoring an NAD+ dependent signaling pathway rather than simply eliminating one protein. Treated mice regained capillary density and saw a 56 to 80 percent boost in endurance. David Sinclair said it (matched by voice) on Joe Rogan Experience #2537 - David Sinclair, aired Aug 7, 2026, at 2:22:35. The supporting source is news.mit.edu, linked below.
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